Extremely Promising News - An Article Just Published Indicates Babies Born From Frozen Eggs Do Not Have An Increase in Congenital Abnomalities

My RE just published this article in conjunction with two Italian REs showing very promising statistics.

Read the summary here:

http://www.rbmonline.com/4DCGI/Article/Detail?38%091%09=%203971%09

RBM Online

Volume 18, No 6 June 2009

Over 900 oocyte cryopreservation babies born with no apparent increase in congenital anomalies

Dr. Nicole Noyes1,4, Dr. Eleonora Porcu2, Dr. Andrea Borini3
1Dept. of OB/GYN, NYU Fertility Center, NYU School of Medicine, 660 First Avenue, Fifth Floor, New York USA 10016
2Infertility/Reproductive Unit, University of Bologna, Bologna, Italy 40138
3Technobios Procreazione, Center for Reproductive Health, Bologna, Italy 40125
4Correspondence: nnoyes01@gmail.com

Over the past decade, the number of reported livebirths resulting from oocyte cryopreservation has rapidly increased. To appreciate the true number of children born, verified livebirths were tabulated and assessed. A literature search was performed; authors were then contacted to verify birth outcomes and provide updates. A database including all verified liveborn infants was constructed. A total of 58 reports (1986–2008) were reviewed, which included 609 liveborn babies (308 from slow-freezing, 289 from vitrification and 12 from both methods). Additionally, 327 other livebirths were verified. Of the total 936 liveborns, 1.3% (12) were noted to have birth anomalies: three ventricular septal defects, one choanal and one biliary atresia, one RubinsteinTaybi syndrome, one ArnoldChiari syndrome, one cleft palate, three clubfoot and one skin haemangioma. Compared with congenital anomalies occurring in naturally conceived infants, no difference was noted. With more liveborn data accumulating, this procedure may become mainstream as a fertility preservation option, particularly for women diagnosed with malignancy requiring cytotoxic therapy. A registry would help to assure the safest, most expeditious development of this technology.


Reproductive BioMedicine Online 2009 http://www.rbmonline.com/Article/3971 [e-pub ahead of print on 8 April 2009]

Reproductive BioMedicine Online 2009 Vol. 18 No.6. 769–776

Keywords: liveborn, oocyte cryopreservation, pregnancy outcome, slow freezing, vitrification

Buy the article here:

http://www.rbmonline.com/4DCGI/Article/2008/3971/RB3971%20Noyes.pdf